Case story database

Search for Successfully Implemented Alternatives

You can use the free text search function to find information in the case story database. Most suitable are: substance name and other substance identifier (EC- and CAS-number). You can refine your search after first entry for sector-, function- and process-categories. The case studies are meant to serve as source of inspiration and ideas for substitution. The alternatives are constantly being developed further. We therefore recommend that you to check in each individual case whether an alternative is suitable for your applications and purposes. If you are aware of any other relevant information that is not mentioned in the current case story, please contact SUBSPORTplus.

In order to utilize information in the best way, please take note of the SUBSPORTplus methodology on case stories!

*For a more precise search, use quotation marks ("example").

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Substitution von N,N-Dimethylformamid durch Ethanol bei der Analyse von alkalischer Phosphatase in Leukozyten

N,N-Dimethylformamid wird bei einem Verfahren verwendet, um die Aktivität des Enzyms alkalische Phosphatase in Leukozyten zu messen. N,N-Dimethylformamid wird speziell als Lösungsmittel eingesetzt, um eine Substratlösung anzusetzen und kann einfach durch Ethanol ausgetauscht werden, ohne dass Änderungen an diesem Arbeitsverfahren notwendig werden. Der einzige Unterschied ist, dass der Lösungsvorgang mit Ethanol etwas langsamer ist als mit N,N-Dimethylformamid.

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Substitution von Toluol, Xylol und Naphtha als Lösungsmittel zur Reinigung von Werkzeugen in einer Autowerkstatt

Dieses Fallbeispiel beschreibt die Substitution von „Safety Clean“ (ein universelles Lösungsmittel, bestehend aus Toluol, Xylol, Naphtha und anderen Inhaltsstoffen). Das Entfettungsmittel wurde in einer Autowerkstatt zur Reinigung von Arbeitswerkzeugen eingesetzt.

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Substitution of toluene, xylene and naphtha as solvents for cleaning tools in garages

This case study describes the substitution of Safety Clean (a universal solvent consisting of toluene, xylene, naphtha and other ingredients). The degreasing agent was used in a garage for cleaning work tools.

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Substitution of N,N-dimethylformamide with ethanol in analysis of alkaline phosphatases in leukocytes.

N,N-dimethylformamide is used in a method to measure activity of the enzyme alkaline phosphatase in leukocytes. N,N-dimethylformamide is specifically used as a solvent to prepare a substrate solution for the method and can easily be substituted with ethanol without any changes in the procedure. The only difference is that ethanol is slightly slower as a solvent than N,N-dimethylformamide.

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Substitution eines naphthabasierten Lösungsmittels für die Reinigung von Druckwalzen

Ein naphthabasiertes Lösungsmittel wurde zur Reinigung von Druckwalzen eingesetzt. Es enthielt Naphtha (krebserzeugend und keimzellmutagen). Das Produkt wurde regelmäßig manuell, auch auf eine gefährliche Art und Weise, verwendet. Es wurde durch ein anderes Lösungsmittel ersetzt, das keine gravierenden Auswirkungen auf die menschliche Gesundheit hat.

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Substitution of a naphtha-based solvent in the cleaning of printing rolls

A naphtha-based solvent was used to clean printing rolls. It contained naphtha (carcinogens), 2-butoxyetanol (endocrine disruptor and neurotoxicant) and volatile organic compounds. The product was handled manually on a regular basis which implied a dangerous practice. It was substituted by another solvent with no significant impact on human health.

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Substitution von Toluol und Butan-1-ol in Farben zum Bedrucken von Plastiktüten

In Druckfarben auf Basis organischer Lösungsmittel zum Bedrucken von Plastiktüten wurden gefährliche Chemikalien gefunden; sie wurden durch wasserbasierte Farben ersetzt, die kein Toluol und Butan-1-ol zum Drucken benötigen.

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Substitution of toluene and butan-1-ol in inks for the printing of plastic bags

Toxic chemicals found in printing inks based on organic solvents used for the printing of plastic shopping bags were replaced by water-based inks, which eliminated toluene and butan-1-ol from the printing process.

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Alternatives to 2-methoxyethanol as put forward by the European Chemicals Agency (ECHA)

This document concerns the general toxicity of 2-methoxyethanol and some common alternatives to its use in different applications. The most common substitutes for 2-methoxyethanol are: PGME, EGBE, ethylene glycol monopropyl ether (EGPE) and their acetates (PGMEA, EGBEA, EGPEA). The decision which alternative to use depends on what application 2-methoxyethanol is currently used in.

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Different ways to phase out halocarbons like dichloromethane in various applications.

This document describes how a large portion of the halocarbons used and manufactured in Sweden were phased out during the late 1980´s and early 1990´s. Several specific examples are mentioned concerning what chemicals were substituted and what the alternatives were. The chemicals discussed are mainly: dichloromethane, trichloroethylene, 1,1,2-Dichloro-1,2,2-trifluoroethane and 1,1,1-trichloroethane.

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