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Search for Successfully Implemented Alternatives

You can use the free text search function to find information in the case story database. Most suitable are: substance name and other substance identifier (EC- and CAS-number). You can refine your search after first entry for sector-, function- and process-categories. The case studies are meant to serve as source of inspiration and ideas for substitution. The alternatives are constantly being developed further. We therefore recommend that you to check in each individual case whether an alternative is suitable for your applications and purposes. If you are aware of any other relevant information that is not mentioned in the current case story, please contact SUBSPORTplus.

In order to utilize information in the best way, please take note of the SUBSPORTplus methodology on case stories!

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Alternatives to 2-methoxyethanol as put forward by the European Chemicals Agency (ECHA)

This document concerns the general toxicity of 2-methoxyethanol and some common alternatives to its use in different applications. The most common substitutes for 2-methoxyethanol are: PGME, EGBE, ethylene glycol monopropyl ether (EGPE) and their acetates (PGMEA, EGBEA, EGPEA). The decision which alternative to use depends on what application 2-methoxyethanol is currently used in.

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Aqueous solution combined with ultrafiltration as an alternative to 4-methylpentan-2-one (MIBK) in purification of penicillin.

4-methylpentan-2-one (MIBK) was used for purification of penicillin in a pharmaceutical production. As an alternative the company used a method, where penicillin becomes water soluble through pH adjustment and then the purification can be made by ultra filtration. In this way MIBK was totally phased out.

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Enzymatic processes versus chemical processes in the preparation of 6-aminopenicillanic acid

This case story describes how using enzymatic processes instead of chemical processes may result in substitution of hazardous substances. Fewer steps during synthesis and low solvent use are the major benefits. Energy savings, fewer safety and disposal issues, and improved product quality also lead to cost benefits.

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