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Search for Successfully Implemented Alternatives

You can use the free text search function to find information in the case story database. Most suitable are: substance name and other substance identifier (EC- and CAS-number). You can refine your search after first entry for sector-, function- and process-categories. The case studies are meant to serve as source of inspiration and ideas for substitution. The alternatives are constantly being developed further. We therefore recommend that you to check in each individual case whether an alternative is suitable for your applications and purposes. If you are aware of any other relevant information that is not mentioned in the current case story, please contact SUBSPORTplus.

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Alternatives to 2-methoxyethanol as put forward by the European Chemicals Agency (ECHA)

This document concerns the general toxicity of 2-methoxyethanol and some common alternatives to its use in different applications. The most common substitutes for 2-methoxyethanol are: PGME, EGBE, ethylene glycol monopropyl ether (EGPE) and their acetates (PGMEA, EGBEA, EGPEA). The decision which alternative to use depends on what application 2-methoxyethanol is currently used in.

GLDA – ein grüner Chelatbildner

GLDA ist ein Chelatbildner neuer Generation, welcher speziell zu Reinigungszwecken als alternative Substanz zu EDTA (Ethylendiamintetraacetat) und zu Phosphonat, eingesetzt werden kann.

Alternatives to Chromic Acid Cleaners in Laboratories

Chromic acid is widely used in many laboratories for cleaning glassware. Because of the hazards for health and environment some alternatives have been developed as commercial products, but also as laboratory-made substitutes.

Substitution eines Reinigungsproduktes, das einen karzinogenen und erbgutverändernden Stoff enthält: Isobuten (enthält > 0,1% Butadien (203-450-8))

Die regionale Gewerkschaft (CC.OO.) führte einen Substitutionsprozess vieler Reinigungsprodukte durch, die im Hauptsitz der Gewerkschaft verwendet wurden. Die Substitution war Teil eines umfassenderen Präventivprojektes, um das Arbeitsrisiko des Reinigungspersonals zu reduzieren. Ein Bodenreinigungsmittel, das den ein karzinogenen und erbgutverändernden Stoff Isobuten (mit einem Gehalt von mindestens 0,1% Butadien (EC-Nummer 203-450-8)), enthielt, wurde durch ein Produkt mit Isopropanol, einen Stoff der weniger Arbeits- und Umweltrisiken birgt, ersetzt.

Substitution of a cleaning product containing isobutane (containing > 0,1 % butadiene (203-450-8)) a carcinogenic and mutagenic substance

The regional trade union (CC.OO.) carried out a substitution process of several cleaning products used in the trade union headquarters. Substitution was part of a broader preventive project to reduce the occupational risks of the cleaning staff.
A floor cleaner containing isobutane (containing > 0,1 % butadiene (203-450-8)), a carcinogen and mutagenic chemical, was replaced by a product containing isopropanol, a chemical with less occupational and environmental hazards.

Im nationalen Zentrum für Gesundheitsdaten und Seuchenschutz in Dänemark (SSI) ausgeführte Substitutionen.

SSI hat es geschafft, Borsäure, Ethidiumbromid und Ether durch Essigsäure, einen nicht-mutagenen DNA-Farbstoff und Natriumhydroxid zu substituieren. Derzeit wird an der Bewertung einer Alternative zu Trypanblau in der Zellfärbung gearbeitet.

Substitutions performed at the National Centre for Health Data and Disease Control in Denmark (SSI)

SSI have managed to substitute boric acid, ethidium bromide and ether with acetic acid, a non-mutagenic DNA dye and sodium hydroxide. They are currently working on validation of an alternative to Trypan Blue in cell staining.

Treating head lice naturally

In many schools and nurseries head louse alarm is regularly signalled. The use of chemicals such as malathion, permethrin and lindane is more dangerous for the health care staff and children because of louses."die umweltberatung" Österreich (Austrian Eco Counselling) had collected and tested alternatives.

Supercritical carbon dioxide as alternative to hexane in herbal substances extraction

Hexane, a good solvent but a flammable and toxic substance was replaced by a company with supercritical carbon dioxide in extracting active ingredients from herbs. The use of extracts for therapeutic purposes means that great attention is paid to the product quality and to eliminating compounds (even impurities) that may have a negative impact on health.

Extraction of Active Pharmaceutical Ingredients (API’s) and other active organic compounds with Supercritical Carbon Dioxide.

Supercritical Fluid Technology utilizing carbon dioxide is highly suitable for extraction of non-polar and low-polar small compounds. The technology allows for organic solvent free extraction at low temperatures, protecting sensitive agents from processing damage.

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