Case story database

Search for Successfully Implemented Alternatives

You can use the free text search function to find information in the case story database. Most suitable are: substance name and other substance identifier (EC- and CAS-number). You can refine your search after first entry for sector-, function- and process-categories. The case studies are meant to serve as source of inspiration and ideas for substitution. The alternatives are constantly being developed further. We therefore recommend that you to check in each individual case whether an alternative is suitable for your applications and purposes. If you are aware of any other relevant information that is not mentioned in the current case story, please contact SUBSPORTplus.

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Substitution von Formaldehyd als Gewebefixiermittel

Formaldehyd ist eine organische Verbindung, die als Gewebefixiermittel in der Mikroskopie und Histologie verwendet wird. Das Formaldehyd wurde durch ein Produkt mit dem gewerblichen Namen Fixall-his substituiert, das Ethanol, Isopropanol und Essigsäure enthält.

Substitution of formaldehyde as a tissue fixative

Formaldehyde is an organic compound used as a tissue fixative for microscopy and histology. Formaldehyde was substituted by a product containing: ethyl alcohol, isopropyl alcohol and acetic acid under the commercial name Fixall-his.

Substitution von N,N-Dimethylformamid durch Ethanol bei der Analyse von alkalischer Phosphatase in Leukozyten

N,N-Dimethylformamid wird bei einem Verfahren verwendet, um die Aktivität des Enzyms alkalische Phosphatase in Leukozyten zu messen. N,N-Dimethylformamid wird speziell als Lösungsmittel eingesetzt, um eine Substratlösung anzusetzen und kann einfach durch Ethanol ausgetauscht werden, ohne dass Änderungen an diesem Arbeitsverfahren notwendig werden. Der einzige Unterschied ist, dass der Lösungsvorgang mit Ethanol etwas langsamer ist als mit N,N-Dimethylformamid.

Substitution of N,N-dimethylformamide with ethanol in analysis of alkaline phosphatases in leukocytes.

N,N-dimethylformamide is used in a method to measure activity of the enzyme alkaline phosphatase in leukocytes. N,N-dimethylformamide is specifically used as a solvent to prepare a substrate solution for the method and can easily be substituted with ethanol without any changes in the procedure. The only difference is that ethanol is slightly slower as a solvent than N,N-dimethylformamide.

Substitution eines Desinfektionsmittels in einem Altenheim

Ein Altenheim nutzte ein Desinfektionsmittel, das unter anderem drei endokrine Disruptoren enthielt. Eine der Arbeitskräfte erlitt Reizungen im Hals und Atembeschwerden. Das Antiseptikum wurde durch ein auf Didecyldimethylammoniumchlorid und ethoxylierten Alkoholen basierendes Produkt substituiert. Diese Stoffe haben keine signifikanten Auswirkungen auf die Gesundheit des Menschen.

Substitution of a disinfectant in a residential home for elderly

A residential institution for elderly used a disinfectant that contained three endocrine disruptors. One of the workers suffered from throat irritation and respiratory problems. The disinfectant was substituted by a product based on didecyldimethylammonium chloride and ethoxylated alcohols, which have no significant effects on human health.

Alternatives to 2-methoxyethanol as put forward by the European Chemicals Agency (ECHA)

This document concerns the general toxicity of 2-methoxyethanol and some common alternatives to its use in different applications. The most common substitutes for 2-methoxyethanol are: PGME, EGBE, ethylene glycol monopropyl ether (EGPE) and their acetates (PGMEA, EGBEA, EGPEA). The decision which alternative to use depends on what application 2-methoxyethanol is currently used in.

Ionic liquids for tissue fixation instead of formalin

1-methyl-3-octyloxymethylimidazolium tetrafluoroborate proved to be a very good tissue fixative. Compared to fixation with formalin it resulted in comparable quality of preparations.

Substitution of subtilisins in manual cleaning of flexible endoscopes in hospitals

In a hospital in the Capital Region of Denmark cleaning of flexible endoscopes with enzymes was substituted by a product based on triethanolamine hereby reducing the risk of allergy. The substitution can only be performed if the succeeding machine wash is not based on aldehydes.

GLDA – a green chelate

Glutamic acid diacetic acid (GLDA) is a new generation of chelating agent that can be used as alternative to EDTA (ethylenediaminetetraacetate) and phosphonates, especially in cleaning applications.

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