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Glossary
Glossary
Halogens
Reactive substances consisting of Fluorine, Chlorine, Bromine, Iodine or Astatine.
Hazard
Intrinsic property of a substance which is always present. See also Risk.
HPV
High Production Volume chemical, manufactured/imported at more than 1000 tonnes/year.
In vivo testing
Testing within a living organism.
IOELV
Indicative Occupational Exposuer Limit Value
KOW
Octanol-Water Partition Coefficient is a coefficient representing the ratio of the solubility of a compound in octanol to its solubility in water. The higher the KOW, the more soluble is the compound in non-polar, organic solvents. Log KOW is generally used as a relative indicator of the tendency of an organic compound to adsorb to soil. Log KOW values are generally inversely related to aqueous solubility and directly proportional to molecular weight.
LOAEC
The Lowest Observed Adverse Effect Concentration is the lowest tested concentration at which there are statistically significant increases in frequency or severity of adverse effects between the exposed population and an appropriate control group.
LOAEL
The Lowest Observed Adverse Effect Level is the lowest tested dose or exposure level at which there are statistically significant increases in frequency or severity of adverse effects between the exposed population and an appropriate control group.
LOEL
The Lowest Observed Effect Level is the lowest tested dose or exposure level at which, in a study, a statistically significant effect is observed in the exposed population compared with an appropriate control group.
LPV
Low Production Volume chemical, manufactured/imported at more than 100 tonnes/year.
Manufacturer
Any national or legal person established within the Community who manufactures a substance within the Community
Manufacturing
Production or extraction of substances in the natural state
Mixture (former designation: preparation)
A solution composed of two or more substances.
MSCA
Member State Competent Authority. The authority in each EU Member state which monitors REACH and other chemical issues.
Mutagenic
Causes irreparable mutations in the DNA which will be transferred on to the next generation.