Case story database

Search for Successfully Implemented Alternatives

You can use the free text search function to find information in the case story database. Most suitable are: substance name and other substance identifier (EC- and CAS-number). You can refine your search after first entry for sector-, function- and process-categories. The case studies are meant to serve as source of inspiration and ideas for substitution. The alternatives are constantly being developed further. We therefore recommend that you to check in each individual case whether an alternative is suitable for your applications and purposes. If you are aware of any other relevant information that is not mentioned in the current case story, please contact SUBSPORTplus.

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Substitution eines Desinfektionsmittels in einem Altenheim

Ein Altenheim nutzte ein Desinfektionsmittel, das unter anderem drei endokrine Disruptoren enthielt. Eine der Arbeitskräfte erlitt Reizungen im Hals und Atembeschwerden. Das Antiseptikum wurde durch ein auf Didecyldimethylammoniumchlorid und ethoxylierten Alkoholen basierendes Produkt substituiert. Diese Stoffe haben keine signifikanten Auswirkungen auf die Gesundheit des Menschen.

Substitution of subtilisins in manual cleaning of flexible endoscopes in hospitals

In a hospital in the Capital Region of Denmark cleaning of flexible endoscopes with enzymes was substituted by a product based on triethanolamine hereby reducing the risk of allergy. The substitution can only be performed if the succeeding machine wash is not based on aldehydes.

Alternatives to Chromic Acid Cleaners in Laboratories

Chromic acid is widely used in many laboratories for cleaning glassware. Because of the hazards for health and environment some alternatives have been developed as commercial products, but also as laboratory-made substitutes.

Alternatives to diethyl ether containing adhesives for electrodes used in electroencephalograms

Exposure to a diethyl ether containing adhesive, used to attach the electrodes in long-term encephalograms (EEG), was incriminated for causing dizziness and headache to nurses but also to patients in two health care units in France. The case describes the exposure during different phases of the EEG, and proposes measures to replace the adhesive or to change the way electrodes are fixed, making the adhesive unnecessary.

Substitution of gasoline with a combination of ethanol based all-purpose cleaner and window cleaner for cleaning of medical equipment.

Gasoline is used to clean medical equipment in hospital and laboratories. It was discovered that gasoline can readily be substituted with an ethanol based all-purpose cleaner. For hospital and laboratory glassware, a window cleaner should also be used for best results.

70% ethanol as an alternative to formalin in tissue fixation

70% ethanol fixation and paraffin embedding is a useful alternative method for molecular profiling studies. This was shown during a systematic approach of processing clinical tissue specimen (prostate and kidney) through non-formalin fixation method.

Substitution of immersion oil containing dibutyl phthalate and chlorinated paraffin with an oil containing benzyl benzoate.

An immersion oil, used in microscopy containing dibutyl phthalate and chlorinated paraffin was substituted with another immersion oil containing only benzyl benzoate at the Uppsala county council. The substitution resulted in safer working environment for the staff.

Substitution of glutaraldehyde with a solution of peracetic acid and hydrogen peroxide as a disinfectant of medical equipment.

Glutaraldehyde has previously been used to disinfect heat-sensitive medical equipment in dishwashers. It was found that glutaraldehyde could be substituted with a solution of peroxyacetic acid and hydrogen peroxide.

Substitution of chromium trioxide with silver nitrate (lunar caustic sticks) for cauterisation of blood vessels to stop heavy nosebleeds.

Chromium trioxide is used to stop bleeding, especially in heavy nosebleeds in a process known as cauterisation. It was found that silver nitrate in the form of lunar caustic sticks can replace chromium trioxide as a cauterisation agent. The use of silver nitrate is associated with some drawbacks, but it is still advantageous compared to chromium trioxide which is highly toxic and carcinogenic.

Reduction of chlorine for disinfection in swimming pools

Chlorine is used as a disinfectant in swimming pools. Chlorine has the advantage of being effective against a considerable number of microorganisms. When adding free chlorine to swimming pool water, however, a very large number of unwanted chlorinated by-products are formed. Other compounds can be used for disinfection, but they are not as efficient and fast-acting as chlorine. But if e.g. silver compounds are combined with a non-chemical alternative as filtration a good result can be achieved.

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