Case story database

Search for Successfully Implemented Alternatives

You can use the free text search function to find information in the case story database. Most suitable are: substance name and other substance identifier (EC- and CAS-number). You can refine your search after first entry for sector-, function- and process-categories. The case studies are meant to serve as source of inspiration and ideas for substitution. The alternatives are constantly being developed further. We therefore recommend that you to check in each individual case whether an alternative is suitable for your applications and purposes. If you are aware of any other relevant information that is not mentioned in the current case story, please contact SUBSPORTplus.

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Substitution von Formaldehyd als Gewebefixiermittel

Formaldehyd ist eine organische Verbindung, die als Gewebefixiermittel in der Mikroskopie und Histologie verwendet wird. Das Formaldehyd wurde durch ein Produkt mit dem gewerblichen Namen Fixall-his substituiert, das Ethanol, Isopropanol und Essigsäure enthält.

Ionic liquids for tissue fixation instead of formalin

1-methyl-3-octyloxymethylimidazolium tetrafluoroborate proved to be a very good tissue fixative. Compared to fixation with formalin it resulted in comparable quality of preparations.

70% ethanol as an alternative to formalin in tissue fixation

70% ethanol fixation and paraffin embedding is a useful alternative method for molecular profiling studies. This was shown during a systematic approach of processing clinical tissue specimen (prostate and kidney) through non-formalin fixation method.

Bio-pitch as replacement for coal tar in the production of electrodes

Bio-pitch can be mixed with char-coal to obtain electrodes. The study presents results of tests carried out with bio-pitch electrodes obtained under various conditions from eucalyptus oil.

Alternative to formaldehyde as preservative in water samples

A well-known preservative, formaldehyde, is also a carcinogen and a sensitiser. Its use for preserving macroinvertebrates in fresh water samples can be substituted by freezing parts of the samples and using ethanol for the other parts.

Substitution of formaldehyde as a tissue fixative

Formaldehyde is an organic compound used as a tissue fixative for microscopy and histology. Formaldehyde was substituted by a product containing: ethyl alcohol, isopropyl alcohol and acetic acid under the commercial name Fixall-his.

Professional drink and vaccine cooling with natural refrigerants

A Danish company produces refrigerators and freezers for professional use; for soft drinks, beer, wine, pharmaceuticals, blood and vaccines, and has offered coolers and freezers with hydrocarbon refrigerants since 1994, and to the household market and since 2000. The company has 330 employees and 90% of the production is exported to the global market.

Alternative to formaldehyde in fluid preservation of biological specimens.

22 alternatives were assessed as alternatives to formaldehyde in preserving biological specimens. DMDM-hydantoin was regarded as a suitable alternative. DMDM-hydantoin is also used in pharmaceutical and cosmetic products.

Substitution von Formaldehyd durch Wasserstoffperoxid zur Dekontamination von biologischen Laboratorien und Tierhaltungsanlagen

Die Dekontamination von Laboratorien und Tierhaltungsanlagen der Schutzstufe 2-4, sowie von HEPA-Filteranlagen (siehe TRBA 100/120) wurde lange Zeit mit Formaldehyd durchgeführt. Formaldehyd kann in einem alternativen Verfahren durch das weniger gefährliche Wasserstoffperoxid unter einfacheren Verwendungsbedingungen substituiert werden.

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